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VIROLOGY (MUHAS PAST PAPER)

VIROLOGY CAT 2022, PAGE 1 of 2

   MD2_CAT_Module II Exam (page 1 of 2)

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Virology, Immunology and Applied Microbiology

Question 1

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Since the emergency of COVID-19, the virus has undergone several evolution by acquiring mutations that has led to emergence of variant of concern and variants of interest. The following is true regarding the current SARS-CoV-2 variants of concerns
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Question 2

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How can the morphology of filoviruses be described?
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Question 3

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Which of the following is required by HDV?
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Question 4

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The order of percent of total immunoglobulin in serum is,
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Question 5

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True regarding the properties of Lentiviruses
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Question 6

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Which of the following immunoglobulin is the main host defense against parasitic infections?
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Question 7

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Which of the following antigenic types of HBV is present in the envelope?
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Question 8

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On September 15, a 49-year-old man visited a neurologist with 2 days of increasing right arm pain and paresthesia. The neurologist diagnosed atypical neuropathy. The symptoms increased and were accompanied by hand spasms and sweating on the right side of the face and trunk. The patient was discharged twice from an emergency department, but symptoms worsened. After developing hypersalivation, agitation, and generalized muscle twitching, the patient was admitted to a local hospital on September 16 with rabies test returning positive. What is the most probable outcome of the patient
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Question 9

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In a neonate with “classic” symptoms of congenital Cytomegalovirus (CMV) infection, which one of the following tests would be most helpful in establishing a diagnosis?
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Question 10

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The membrane attack complex in the complement pathway consists of:
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Question 11

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The defective satellite virus is?
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Question 12

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Regarding HIV therapy, the following are nRTIs EXCEPT: –
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Question 13

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Which one of the following is not considered in classification of Retroviridae
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Question 14

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Within the innate immune response, this cell acts by killing virus-infected cells
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Question 15

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Viruses are obligate intracellular organisms that require the presence of a specific receptor expressed on the target host cell surface for entry into the target cell. Which of the is not the correct pair of virus-specific host cell receptor?
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Question 16

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The classical and alternative pathways meet at complement component:
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Question 17

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How can you confirm an infection due to slow growing viruses?
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Question 18

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One of the following viruses is most likely to cause perinatal infections
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Question 19

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A lesion in the temporal lobe and brain biopsy showed multinucleated giant cells with intranuclear inclusion bodies is most likely caused by:-?
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Question 20

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The following are the antigenic structure for measles EXCEPT?
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Question 21

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DNA virus is a virus that has a genome made of deoxyribonucleic acid that is replicated by a DNA polymerase. The following virus is not an example of a DNA virus
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Question 22

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Which of the following is most accurate about Ebola virus?
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Question 23

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A poultry farmer in China experienced fatigue, malaise, sore throat, and fever. During the past 2 weeks, his poultry farm had to kill all of its chickens because of a sudden virus outbreak that almost decimated the entire flock. A neighboring farmer raises swine. The virus infecting the chicken farmer arose by antigenic shift. Which of the following best describes this process?
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Question 24

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How can a B cell be distinguished from a T cell?
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Question 25

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Infectious mononucleosis is characterized by which of the following statements?
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Question 26

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Although smallpox virus has been eradicated it is considered as a bioterrorism agent. The following is not correct regarding the properties of smallpox virus
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Question 27

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A sudden outbreak of the H5N2 influenza virus occurred in Hong Kong, requiring the killing of millions of chickens. Which of the following would rapidly prevent disease in the owners of these chickens?
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Question 28

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Regarding HIV replication one of the following gene is responsible for transportation of the late mRNA from the nucleus to the cytoplasm is: –
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Question 29

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Worldwide 3 to 5 million cases of severe influenza illnesses and 250,000 to 500,000 deaths occur annually. Great effort is made annually to prepare influenza vaccines against circulating strains of Influenza virus A and B. Yet, in some years, the vaccine is less effective in neutralizing the virus even though the circulating strains are the same type as that from the previous year; that is, both are H1N1 or both are H2N3. Which of the following mechanisms is responsible for this problem?
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Question 30

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Epstein-Barr Virus (EBV) is associated with all of the following EXCEPT
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Question 31

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A 3 year old baby girl who attends day care presents with watery diarrhoea and nausea for 2 days. Her mother reports that she was informed by the school manager that there is a diarrhoea outbreak at the school. On physical examination she looks irritable, looks eager to drink water. The attending clinician has a provisional diagnosis of diarrhoea with mild dehydration and the baby was managed accordingly, 3 days later diarrhoea resolved. Which of the following is the likely aetiology of the diarrhoea
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Question 32

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A HIV infected eight-year-old child was infected with adenovirus, and showed symptoms of upper respiratory tract infection. This cleared after a few days, 11 years later a tumor mass which was identified to be malignant was incisioned from his chest, which adenovirus is was likely isolated from the tumor?
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Question 33

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They usually cause rare diseases of neurological origin
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Question 34

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What is a characteristic of the adaptive immune response and not of the innate response?
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Question 35

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Reactivation of VZV is known to occur in persons receiving immunosuppressive therapy. Which of the following is the best antiviral for treating this infection?
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Question 36

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A 38-year-old woman is diagnosed with cervical cancer. Common malignant aetiology of human cervical cancer is:
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Question 37

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Which of the following combinations is a representative of highly active retroviral therapy?
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Question 38

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A patient diagnosed with influenza reported onset of symptoms 18 hours ago. Which of the following is the most appropriate treatment for this patient?
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Question 39

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The specialized cell type involved in the entry of lymphocytes into lymph nodes are called:
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Question 40

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True about Sabin vaccine for Polio
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Question 41

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One of the biological consequences of the antigen-antibody reaction
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Question 42

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As part of the innate immune response, which cells participate in phagocytosis?
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Question 43

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Koplik spots are pathognomonic features of which of the following
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Question 44

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Which of the following genetic mechanisms promotes the development of a pandemic strain of influenza A?
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Question 45

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Molecular testing (RT-PCR) of SARS-CoV-2 that detects the spike protein and nucleocapsid is the most definitive and gold standard test for diagnosis of acute SARS-CoV-2 infection. The highest detection of the viral genome is usually in….of the infection
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Question 46

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An example of a known oncogenic virus is:
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Question 47

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A first year student at MUHAS went to a clinic to test for HIV. In the lab the available ELISA kit was coated with antibodies. What type of ELISA will be performed to give out the results?
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Question 48

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Which of the following statements concerning yellow fever is correct?
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Question 49

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Which of the following factors promotes the need for a new annual influenza A vaccine?
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Question 50

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Depending on the genomic properties and availability of viral enzymes the viruses can either replicate in the cytoplasm or within the nucleus of the target cell. Which of the following viruses replication takes place in the cytoplasm?
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